In the late 20th century, the U.S. saw declining mortality rates for midlife and older adults, but from 1999 to 2013, a troubling trend emerged. Middle-aged non-Hispanic whites experienced a notable increase in all-cause mortality due to suicides, drug addiction, and alcoholism. This phenomenon, known as ”deaths of despair,” disproportionately affected those with lower socioeconomic status and extended to uneducated whites, as highlighted by Case and Deaton’s (2021) research. Our project explores how causes of death change over time and across demographic groups among midlife citizens and examines the extent of ”deaths of despair.” Our findings align with previous research, showing that cancer and heart disease remained the top two causes of death, but their overall proportion decreased over time due to the emergence of other diseases. Additionally, our research indicates that suicide, drug, and alcohol-induced causes of death are closely linked to the low-education group and non-white populations.